Region IV is comprised of chapters and members that are located in Minnesota, Illinois, Indiana, Michigan, Ohio, Wisconsin,  Central Canada, Central Africa, East Africa.

It is home to several of the top colleges and universities in the country including Purdue University, the University of Illinois, Northwestern University, the University of Michigan, and the University of Minnesota, and the Ohio State University all of which have vibrant NSBE chapters.

It is also the location of a host of solid engineering companies like Boeing, Rockwell Automation, Ford Motors, Cummins, and Procter & Gamble to name a few.

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