Region III is comprised of chapters and members that are located in Alabama, Georgia, Florida, Kentucky, Mississippi, Tennessee, the Caribbean, and South America

It is home to several of the top colleges and universities in the country including Georgia Tech, Tuskegee, Vanderbilt, Morehouse, Florida State, Tennessee State, the University of Kentucky and Jackson State.

It is also the location of a host of engineering powerhouses like Electronic Arts, Google, Lockheed Martin, Microsoft, NASA, Northrop Grumman, Oracle, Verizon, and Veritas to name a few.